Glenn sends us searching for the fountain of youth:
FASTER, PLEASE: Anti-aging formula slated to begin human trials.
And from the link:
A regular metabolic compound that has been administered to mice has been shown to not just boost muscle function, but actually reverse the affects of aging. The research was led by David Sinclair of the University of New South Wales and the results have been published in the journal Cell.
A regular metabolic coenzyme known as nicotinamide adenine dinucleotide (NAD+) was administered to mice in hopes that it would slow the aging of skeletal muscle. The researchers were shocked to find that it didn’t slow aging; it dramatically reversed it. In under a week, the mice who had previously been suffering from a variety of age-related impairments experienced an increase in muscle tone, as if they had been exercising and following a healthy diet. In some regards, the compound acted like the proverbial fountain of youth.
So what is this "regular metabolic coenzyme" and how was it administered? From the paper, we glean this:
Here we evaluated whether similar effects could be achieved by increasing the supply of nicotinamide riboside (NR), a recently described natural NAD + precursor with the ability to increase NAD + levels, Sir2-dependent gene silencing, and replicative life span in yeast.
Their discussion includes this:
In conclusion, our work shows that NR is a powerful supplement to boost NAD+ levels, activate sirtuin signaling, and improve mitochondrial function, suggesting that this vitamin could be used to prevent and treat the mitochondrial decline that is a hallmark of many diseases associated with aging. Very recent work, showing that intraperitoneal administration of NMN could improve the metabolic damage induced by high-fat feeding (Yoshino et al., 2011), further supports this concept. To date, however, only NR has been identified as a naturally occurring component of the human diet (Bieganowski and Brenner, 2004).
Furthermore, NR protects against metabolic dysfunction at lower concentrations than those reported for NMN, and we proved that it is effective after oral administration when mixed with food, in contrast to NMN, which is injected intraperitoneally (Yoshino et al., 2011).
Hmm. While we await their human trials, let's note this press release from last summer:
Jun 27, 2013 (ACCESSWIRE via COMTEX) -- New Ingredient Backed by Scientific Evidence May Have Wide Appeal as a Dietary Supplement and Food Additive
There is, however, a genuinely innovative ingredient that has the promise to deliver pronounced results without invasive procedures or significant expense. It is NIAGEN™ from ChromaDex (otcqb:CDXC), which was introduced this month as the first and only commercially available form of nicotinamide riboside. Also called NR, nicotinamide riboside is a metabolic booster found in milk and whey. Often referred to as a "miracle molecule", NR shows promise in research studies to help address many of the symptoms associated with aging and health care in general: obesity, cholesterol, muscle loss, energy decline, insulin sensitivity and more.
So that's what you want, but can you buy it? Yes and no. Swanson Helath Products offers it, but don't worry about Christmas delivery - it is currently on back order.
Well, I've made it this long; I should be good for a few more weeks. Which leaves time to read about other means of manipulating these things.
And please - don't blow up your liver.